Andrews N C, Erdjument-Bromage H, Davidson M B, Tempst P, Orkin S H
Children's Hospital, Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115.
Nature. 1993 Apr 22;362(6422):722-8. doi: 10.1038/362722a0.
Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.
珠蛋白基因在发育中的红细胞中的表达受上游基因座控制区的调控。这些区域在体内的活性需要一种红细胞特异性核因子（NF-E2），该因子能结合AP-1样识别位点。其组织特异性成分（p45 NF-E2）已通过互补DNA克隆鉴定为一种新的碱性区域-亮氨酸拉链蛋白，它与一种普遍存在的伴侣二聚化形成天然的NF-E2。
