Weiner W J, Singer C, Sanchez-Ramos J R, Goldenberg J N
University of Miami School of Medicine, Department of Neurology, FL 33136.
Neurology. 1993 Apr;43(4):674-7. doi: 10.1212/wnl.43.4.674.
Previous reports and the Physicians' Desk Reference caution against the use of levodopa in Parkinson's disease (PD) patients with melanoma. A critical review of the literature reveals only anecdotal evidence to support a link between levodopa and melanoma. In fact, levodopa has an antitumor effect on melanoma. We report nine patients with PD and melanoma who were treated with levodopa/carbidopa (L/C). Current evidence suggests that L/C can be used safely in PD patients with a history of melanoma.
既往报告及《医师案头参考》均警示帕金森病（PD）合并黑色素瘤患者使用左旋多巴。对文献的严格审查仅发现一些轶事证据支持左旋多巴与黑色素瘤之间的关联。事实上，左旋多巴对黑色素瘤具有抗肿瘤作用。我们报告了9例接受左旋多巴/卡比多巴（L/C）治疗的PD合并黑色素瘤患者。目前的证据表明，有黑色素瘤病史的PD患者可安全使用L/C。
