Kleinhans M, Schmid-Grendelmeier P, Burg G
Dermatologische Klinik, Universitätsspital, Zürich.
Hautarzt. 1996 Jun;47(6):432-7. doi: 10.1007/s001050050446.
A 72-years old man with Parkinson's disease was treated with levodopa for 14 years. A superficial spreading melanoma (Breslow depth 1,8 mm Clark level IV) was diagnosed, developing on the back from a pigment lesion which had present for more than 10 years. Other case reports suggest a relationship between the administration of levodopa and the growth of malignant melanoma. On the other hand, epidemiological studies found no correlation. Furthermore, in vitro and in vivo studies have shown a possible anti-tumor effect of levodopa. Critical analysis of the literature leads to the conclusion, that there is no increased melanoma risk from levodopa.
一名患有帕金森病的72岁男性接受左旋多巴治疗14年。诊断出浅表扩散性黑色素瘤（ Breslow深度1.8毫米，Clark分级IV级），由背部一个已存在10多年的色素病变发展而来。其他病例报告表明左旋多巴的使用与恶性黑色素瘤的生长之间存在关联。另一方面，流行病学研究未发现相关性。此外，体外和体内研究表明左旋多巴可能具有抗肿瘤作用。对文献的批判性分析得出结论，即使用左旋多巴不会增加患黑色素瘤的风险。
