Kuzniecky R, Murro A, King D, Morawetz R, Smith J, Powers R, Yaghmai F, Faught E, Gallagher B, Snead O C
UAB Epilepsy Center, University of Alabama, Birmingham.
Neurology. 1993 Apr;43(4):681-7. doi: 10.1212/wnl.43.4.681.
We conducted a retrospective single-blind study assessing the value of MRI in 44 children surgically treated for partial epilepsy, and correlated the MRI findings with the pathology in all cases. MRI revealed abnormalities in concordance with the clinical and electroencephalographic data in 84% of patients. Developmental neuronal migration pathology was present in 25% of patients and was relatively more common in the sensorimotor cortex. There was hippocampal sclerosis in 50% of patients with temporal lobe resection; however, only two of the 10 children with hippocampal sclerosis were below the age of 12 years. Similarly, ganglio-glial tumors were more common than astrocytomas in children below age 12. These results indicate that MRI is sensitive in the detection of pathologic abnormalities in most pediatric candidates for epilepsy surgery, and that the distribution and type of pathology appear to be age related in this population.
我们进行了一项回顾性单盲研究，评估磁共振成像（MRI）在44例接受部分性癫痫手术治疗儿童中的价值，并将所有病例的MRI结果与病理结果进行关联。MRI显示，84%的患者存在与临床和脑电图数据相符的异常。25%的患者存在发育性神经元迁移病理改变，且在感觉运动皮层相对更常见。50%接受颞叶切除术的患者存在海马硬化；然而，10例海马硬化患儿中只有2例年龄在12岁以下。同样，在12岁以下儿童中神经节胶质细胞瘤比星形细胞瘤更常见。这些结果表明，MRI在大多数癫痫手术候选患儿中对病理异常的检测具有敏感性，并且在该人群中病理改变的分布和类型似乎与年龄相关。
