Cross J H, Jackson G D, Neville B G, Connelly A, Kirkham F J, Boyd S G, Pitt M C, Gadian D G
Institute of Child Health, London.
Arch Dis Child. 1993 Jul;69(1):104-9. doi: 10.1136/adc.69.1.104.
The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children with clinical features of temporal lobe epilepsy and in six of the seven children with clinically unlocalised epilepsy. By contrast, in the four children with a clinical diagnosis of extratemporal epilepsy, no temporal or hippocampal abnormalities were seen. Generalised cortical abnormalities of uncertain significance were found in a total of 14 children from all groups. The identification of focal brain abnormalities using optimised magnetic resonance imaging enables early non-invasive assessment of children with intractable seizure disorders and the identification of patients for whom epilepsy surgery may be appropriate. It may also lead to a better understanding of the structural basis of intractable epilepsy, and thereby contribute to early treatment decisions.
报告了30例连续出现顽固性复杂部分性癫痫发作的儿童经磁共振成像确定的脑异常发生率。图像经过优化以可视化海马体和皮质灰质。在所有19例具有颞叶癫痫临床特征的儿童以及7例临床定位不明确的癫痫儿童中的6例中，均可见海马体或颞叶异常。相比之下，在4例临床诊断为颞外癫痫的儿童中，未发现颞叶或海马体异常。在所有组的总共14名儿童中发现了意义不确定的广泛性皮质异常。使用优化的磁共振成像识别局灶性脑异常能够对患有顽固性癫痫障碍的儿童进行早期非侵入性评估，并识别出可能适合进行癫痫手术的患者。这也可能有助于更好地理解顽固性癫痫的结构基础，从而有助于早期治疗决策。
