Jones R S, Bühl E H
University Department of Pharmacology, University of Oxford, UK.
Neurosci Lett. 1993 Jan 4;149(1):35-9. doi: 10.1016/0304-3940(93)90341-h.
Spiny stellate neurones of layer II of the entorhinal cortex (EC) provide the perforant path input to the dentate gyrus. Previous studies have shown that synaptic responses of these neurones are dominated by GABAergic inhibition. The present study describes intracellular recordings from 'fast-spiking' interneurones in layer II which may be the basis of the synaptic inhibition. Lucifer yellow fills of fast-spiking cells revealed neurones with a widespread axonal arborization forming basket-like complexes around unlabelled cells in layer II. Synaptic activation of the fast-spiking cells evoked long duration excitations which were mediated largely by NMDA receptors. A fast AMPA/kainate EPSP was also detectable. These neurones have morphological and physiological properties which make them well-suited to exert a widespread inhibitory control over the efferent output of layer II to the dentate gyrus.
内嗅皮质（EC）第II层的多棘星状神经元为齿状回提供穿通通路输入。先前的研究表明，这些神经元的突触反应主要受GABA能抑制作用的支配。本研究描述了对第II层“快速放电”中间神经元的细胞内记录，这些中间神经元可能是突触抑制的基础。用荧光黄填充快速放电细胞后发现，这些神经元具有广泛的轴突分支，在第II层未标记的细胞周围形成篮状复合体。快速放电细胞的突触激活诱发了长时间的兴奋，这主要由NMDA受体介导。还可检测到快速的AMPA/海人藻酸兴奋性突触后电位（EPSP）。这些神经元具有形态学和生理学特性，使其非常适合对第II层至齿状回的传出输出施加广泛的抑制性控制。
