声刺激后外毛细胞突触前区域的超微结构变化。

Ultrastructural changes in the presynaptic region of outer hair cells after acoustic stimulation.

作者信息

Canlon B, Löfstrand P, Borg E

机构信息

Department of Physiology II, Karolinska Institute, Stockholm, Sweden.

出版信息

Neurosci Lett. 1993 Feb 5;150(1):103-6. doi: 10.1016/0304-3940(93)90118-5.

DOI:10.1016/0304-3940(93)90118-5

PMID:8469392

Abstract

Protection against noise trauma results by sound-conditioning animals to a low-level, long-term acoustic stimulus prior to a damaging exposure. It is known that the outer hair cells are selectively protected by sound-conditioning. The aim of the present study was to determine if the intrinsic properties of the outer hair cell had been modified by sound-conditioning. A stimulus-related increase in the vesicle content in the presynaptic region was found. It is suggested that the outer hair cells are involved in sound conditioning and that changes in the presynaptic region can be one correlate to the protection against noise trauma by sound-conditioning.

摘要

通过在动物遭受损伤性噪声暴露之前，使其适应低强度、长期的声学刺激，可实现对噪声性创伤的防护。已知外毛细胞会受到声音预处理的选择性保护。本研究的目的是确定外毛细胞的内在特性是否因声音预处理而发生了改变。研究发现，突触前区域的囊泡含量会随着刺激而增加。这表明外毛细胞参与了声音预处理，并且突触前区域的变化可能是声音预处理防止噪声性创伤的一个相关因素。