Warn J D, Fan Q, Smith P G
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160-7401, USA.
Neurosci Lett. 1997 Aug 22;232(1):25-8. doi: 10.1016/s0304-3940(97)00566-1.
Neural control of tissue perfusion is mediated predominantly by sympathetic vasoconstrictor and, in some tissues, parasympathetic vasodilator systems. The objective of this study was to determine if changes occur within parasympathetic vasodilator neurons supplying cranial vessels after sympathectomy. Cranial sympathetic innervation was excised unilaterally, and 6 weeks later pterygopalatine ganglion neurons were evaluated for expression of neuronal nitric oxide synthase immunoreactivity (NOS-ir) and NADPH-diaphorase activity. Relative to the unoperated side, the number of parasympathetic neurons staining densely either for NOS or for NADPH-diaphorase decreased by 37% and 47%, respectively, whereas unstained somata increased by 51% and 48%. Internal carotid artery NOS-ir innervation density was reduced by 35%. These findings are consistent with a down-regulation of nitrergic properties in some cranial parasympathetic neurons after sympathectomy.
组织灌注的神经控制主要由交感缩血管系统介导，在某些组织中还由副交感舒血管系统介导。本研究的目的是确定交感神经切除术后，供应颅部血管的副交感舒血管神经元是否发生变化。单侧切除颅部交感神经支配，6周后评估翼腭神经节神经元中神经元型一氧化氮合酶免疫反应性（NOS-ir）和NADPH-黄递酶活性的表达。相对于未手术侧，NOS或NADPH-黄递酶染色浓密的副交感神经元数量分别减少了37%和47%，而未染色的胞体分别增加了51%和48%。颈内动脉NOS-ir神经支配密度降低了35%。这些发现与交感神经切除术后一些颅部副交感神经元中一氧化氮能特性的下调一致。
