Feasey-Truger K J, Kargl L, ten Bruggencate G
Physiologisches Institut, Universität München, FRG.
Neurosci Lett. 1993 Mar 5;151(1):25-8. doi: 10.1016/0304-3940(93)90036-k.
An 8-arm radial maze was used to examine the effects of dentate kindling on the performance of a task which requires both working (short-term) and reference (long-term) memory. During the 4-week post-operative training period, control and experimental rats performed both components of the task equally well. Performance of the reference memory component, but not the working memory component of the task was significantly impaired during kindling stimulation. The impairment in reference memory appeared to be primarily due to the elicitation of afterdischarges, since the disruption in maze performance was evident in the pre-convulsive stages of kindling. Following the cessation of kindling stimulation, a gradual recovery in reference memory performance was observed. Dentate kindling may provide a useful model for the study of long-term memory deficits associated with temporal lobe epilepsy.
使用八臂放射状迷宫来检验齿状回点燃对一项需要工作（短期）记忆和参考（长期）记忆的任务表现的影响。在术后4周的训练期内，对照大鼠和实验大鼠在任务的两个部分表现同样良好。在点燃刺激期间，任务的参考记忆部分而非工作记忆部分的表现显著受损。参考记忆的损害似乎主要是由于后放电的诱发，因为在点燃的惊厥前期迷宫表现的破坏就很明显。点燃刺激停止后，观察到参考记忆表现逐渐恢复。齿状回点燃可能为研究与颞叶癫痫相关的长期记忆缺陷提供一个有用的模型。
