Plaxe S C, Braly P S, Freddo J L, McClay E, Kirmani S, Howell S B
Department of Reproductive Medicine, University of California, San Diego.
Obstet Gynecol. 1993 May;81(5 ( Pt 1)):651-4.
To study a group of women diagnosed with epithelial ovarian cancer at a young age (less than 40).
Tumor registry data were analyzed with respect to age at diagnosis, stage, grade, frequency of nulligravidity, and family history of breast or ovarian cancer. Frequencies were analyzed using contingency tables, and survival distributions were analyzed according to the method of Kaplan and Meier. Multivariate survival analysis was performed with the Cox method.
We found significantly higher frequencies of low-grade tumors (90 versus 37%; P = .0003, chi 2 test) and early-stage tumors (45 versus 17%; P = .03, Fisher exact test) in women less than 30 at the time of diagnosis (very young patients) than in those between 30-39. We also found a significant (P = .017, Breslow statistic) survival advantage for the very young women. Multivariate analysis demonstrated tumor grade as the independent variable for survival.
These findings support the concept of a preclinical phase of epithelial carcinoma and show that young women may derive substantial benefit from ovarian cancer screening programs.
研究一组被诊断为上皮性卵巢癌的年轻女性（年龄小于40岁）。
分析肿瘤登记数据，内容包括诊断时的年龄、分期、分级、未孕频率以及乳腺癌或卵巢癌家族史。使用列联表分析频率，并根据Kaplan和Meier方法分析生存分布。采用Cox方法进行多变量生存分析。
我们发现，诊断时年龄小于30岁（非常年轻的患者）的女性中，低级别肿瘤（90%对37%；P = 0.0003，卡方检验）和早期肿瘤（45%对17%；P = 0.03，Fisher精确检验）的频率显著高于30 - 39岁的女性。我们还发现非常年轻的女性有显著的生存优势（P = 0.017，Breslow统计量）。多变量分析表明肿瘤分级是生存的独立变量。
这些发现支持上皮癌临床前期的概念，并表明年轻女性可能从卵巢癌筛查项目中获得实质性益处。
