早期上皮性卵巢癌患者的生育力保存。
Fertility preservation in patients with early epithelial ovarian cancer.
机构信息
Department of Obstetrics and Gynecology, College of Medicine, Kwandong University, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea.
出版信息
J Gynecol Oncol. 2009 Mar;20(1):44-7. doi: 10.3802/jgo.2009.20.1.44. Epub 2009 Mar 31.
OBJECTIVE
To assess the role of fertility preservation in the treatment of patients with early epithelial ovarian cancer (EOC).
METHODS
We retrospectively analyzed the medical records of 21 patients with early EOC from January 1995 to December 2006. All eligible patients with a strong desire to preserve fertility were younger than 35 years and underwent fertility-sparing surgery with or without adjuvant chemotherapy.
RESULTS
Twenty-one eligible patients with a median age of 26.7 years (range, 20 to 33 years) were identified, and the mean follow-up period was 43 months (range, 5 to 86 months). Only one patient with stage IC recurred 34 months after the first operation. A total of five patients were able to become pregnant at least once after the first fertility preserving treatment, with or without adjuvant chemotherapy. All five patients succeeded in full-term vaginal delivery with healthy infants. No patients died of their disease.
CONCLUSION
Fertility preserving treatment in patients with early EOC can be considered as a proper treatment strategy in patients with early EOC, who have the strong desire for fertility preservation.
目的
评估生育力保存在早期上皮性卵巢癌（EOC）治疗中的作用。
方法
我们回顾性分析了 1995 年 1 月至 2006 年 12 月期间 21 例早期 EOC 患者的病历。所有符合条件且有强烈生育力保存意愿的患者年龄均小于 35 岁，并接受了保留生育功能的手术，或联合或不联合辅助化疗。
结果
确定了 21 例符合条件的患者，中位年龄为 26.7 岁（范围为 20 至 33 岁），平均随访时间为 43 个月（范围为 5 至 86 个月）。仅 1 例 IC 期患者在首次手术后 34 个月复发。共有 5 例患者在首次生育力保存治疗后至少怀孕一次，无论是否联合辅助化疗。这 5 例患者均成功进行了足月阴道分娩，产下健康婴儿。无患者死于疾病。
结论
对于有强烈生育力保存意愿的早期 EOC 患者，生育力保存治疗可以被视为一种合适的治疗策略。
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