Murdoch-Kinch C A, Miles D A, Poon C K
Indiana University School of Dentistry, Indianapolis.
Oral Surg Oral Med Oral Pathol. 1993 Mar;75(3):403-6. doi: 10.1016/0030-4220(93)90159-2.
The ectodermal dysplasias are a clinically and genetically heterogeneous group of more than 120 syndromes involving ectodermally derived structures. The syndrome that is autosomal dominantly inherited and characterized by hypodontia, dysplastic nails, and normal hair is known as hypodontia-nail dysplasia syndrome, or tooth-and-nail syndrome. Because of the minimal manifestations, this syndrome may be difficult to diagnose. Patients with hypodontia should be examined for dysplastic nails of the hands and feet and referred to medical and dental genetic specialists for verification of the diagnosis and counseling. We report a case of tooth-and-nail syndrome in a young woman.
外胚层发育异常是一组临床和遗传异质性的综合征，有120多种，累及外胚层来源的结构。常染色体显性遗传、以牙发育不全、指甲发育异常和毛发正常为特征的综合征被称为牙发育不全-指甲发育异常综合征，或牙-甲综合征。由于临床表现轻微，该综合征可能难以诊断。牙发育不全的患者应检查手足指甲是否发育异常，并转诊至医学和牙科遗传学专家处进行诊断核实和咨询。我们报告了一名年轻女性患牙-甲综合征的病例。
