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[1戈瑞剂量伽马辐射后期大鼠脂肪组织和肝脏质膜的物理化学状态。脂质组成的变化]

[The physicochemical status of the plasma membranes of rat fatty tissue and liver in the late periods after gamma irradiation at a dose of 1 Gy. Changes in the lipid composition].

作者信息

Egutkin G G, Iakubovskiĭ S M, Samburskiĭ S S, Gatsko G G

出版信息

Radiobiologiia. 1993 Jan-Feb;33(1):55-60.

PMID:8469748
Abstract

A study was made of lipid composition of plasma membranes of adipose tissue and liver of rats at remote times (from 15 to 380 days) after single 1-Gy gamma irradiation. The changes in membrane lipids were most pronounced during the first 50 days after irradiation: the cholesterol level increased (the phospholipid content in the adipose tissue decreased) and the relative content of linoleic (18:2), arachidonic (20:4) and other unsaturated fatty acids decreased. At later times following irradiation, the molar cholesterol/phospholipid ratio in membranes of experimental animals did not vary from the control and relative content of unsaturated fatty acids somewhat increased as compared to that of intact animals of the same age.

摘要

对单次1戈瑞γ射线照射后不同时间(15至380天)大鼠脂肪组织和肝脏质膜的脂质组成进行了研究。照射后前50天膜脂质变化最为明显:胆固醇水平升高(脂肪组织中磷脂含量降低),亚油酸(18:2)、花生四烯酸(20:4)和其他不饱和脂肪酸的相对含量降低。照射后的后期,实验动物膜中的胆固醇/磷脂摩尔比与对照组无差异,与同龄完整动物相比,不饱和脂肪酸的相对含量有所增加。

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