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[1 Gy剂量γ射线照射后晚期大鼠脂肪组织和肝脏质膜的物理化学状态。膜的结构变化]

[The physicochemical status of the plasma membranes of rat fatty tissue and liver in the late periods after gamma irradiation at a dose of 1 Gy. Structural changes in the membranes].

作者信息

Egutkin G G, Iakubovskiĭ S M, Gatsko G G

出版信息

Radiobiologiia. 1993 Jan-Feb;33(1):61-5.

PMID:8469749
Abstract

The structural status of plasma membranes of adipose tissue and liver of rats was investigated at remote times (from 15 to 380 days) after single 1-Gy gamma irradiation. The structural status was estimated by pyrene excimerisation parameters and also by both induction resonance energy transfer method and membrane tryptophan fluorescence spectral characteristics. On days 50-100 following irradiation the microviscosity of a lipid phase of membranes increased and the mode of lipid/protein interactions changed, whereas at later times the indices under study did not vary from the controls. Comparison of the data obtained with the former results on lipid content changes indicates that the physicochemical status of plasma membranes in rat adipose tissue and liver is modified at remote times following 1-Gy gamma irradiation.

摘要

在单次1戈瑞γ射线照射后的不同时间(15至380天),对大鼠脂肪组织和肝脏的质膜结构状态进行了研究。通过芘激基缔合物参数、诱导共振能量转移方法以及膜色氨酸荧光光谱特征来评估结构状态。照射后50至100天,膜脂相的微粘度增加,脂质/蛋白质相互作用模式发生变化,而在随后的时间里,所研究的指标与对照组无差异。将所得数据与之前关于脂质含量变化的结果进行比较表明,1戈瑞γ射线照射后很长一段时间,大鼠脂肪组织和肝脏质膜的物理化学状态发生了改变。

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