Davey B L, Bates J H
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Respir Physiol. 1993 Mar;91(2-3):165-82. doi: 10.1016/0034-5687(93)90097-t.
We developed a technique for applying forced oscillations in flow between 5 and 200 Hz to the lung through an alveolar capsule. This provided measures of the complex alveolar input impedance of the lung, which we modelled in terms of an elastic alveolar unit connected to the rest of the lung by a peripheral airway. The estimated elastance of the alveolar compartment in 6 normal dogs was about 5 orders of magnitude greater than the elastance of the entire lung. The resistance of the airway leading into the compartment from the rest of the lung was about 5 orders of magnitude greater than the resistance of the entire airway tree. The capsule oscillation technique thus gives mechanical information about an extremely small region of the lung (in the order of 10 mm3 in volume) just under the capsule. A bolus i.v. injection of methacholine caused a variable response in the alveolar regions studied, with some regional elastances and resistances increasing while others decreased, despite the fact that overall lung resistance and elastance always increased. We conclude that our capsule oscillator technique yields precise mechanical information about very small distal regions of the lung, and that these regions respond heterogeneously to injected methacholine.
我们研发了一种技术，可通过肺泡囊对肺部施加5至200赫兹之间的强迫振荡气流。这提供了肺部复杂肺泡输入阻抗的测量值，我们根据一个通过外周气道与肺部其他部分相连的弹性肺泡单元对其进行建模。6只正常犬肺泡腔的估计弹性比整个肺部的弹性大约高5个数量级。从肺部其他部分通向该腔的气道阻力比整个气道树的阻力大约高5个数量级。因此，囊振荡技术可提供有关囊下方肺部极小区域（体积约为10立方毫米）的力学信息。静脉注射大剂量乙酰甲胆碱在所研究的肺泡区域引起了可变反应，尽管总体肺阻力和弹性总是增加，但一些区域的弹性和阻力增加，而另一些区域则下降。我们得出结论，我们的囊振荡器技术可产生有关肺部非常小的远端区域的精确力学信息，并且这些区域对注射的乙酰甲胆碱反应各异。
