Nseyo U O, Whalen R K, Lundahl S L
Department of Urology, University of California, Davis.
Urology. 1993 Apr;41(4):392-6. doi: 10.1016/0090-4295(93)90607-c.
A normal canine bladder model was used to compare the effects of red and green light whole bladder photodynamic therapy (PDT). Eighteen dogs were treated with Photofrin 1 mg/kg and whole bladder irradiation with red or green light at doses ranging from 20 to 60 J/cm2. Toxicity was assessed using cystometry, cystoscopy, and histopathology. Green light produced more significant vesical toxicity than red light, and this toxicity tended to vary with the light dose administered. Whole bladder PDT with green light at doses greater than 20 J/cm2 resulted in permanent reductions in bladder capacity. Conversely, a green light dose of 20 J/cm2 and red light doses ranging from 20 to 60 J/cm2 did not produce any significant permanent reductions in bladder capacity. Thus, while green light may be more toxic to the bladder than red light, there are distinct combinations of red or green light and Photofrin which can be used in the canine bladder to achieve mucosal degradation without causing permanent vesical dysfunction.
使用正常犬膀胱模型比较红光和绿光全膀胱光动力疗法（PDT）的效果。18只犬接受1mg/kg的卟吩姆钠治疗，并分别用红光或绿光以20至60J/cm²的剂量进行全膀胱照射。使用膀胱测压法、膀胱镜检查和组织病理学评估毒性。绿光比红光产生更显著的膀胱毒性，并且这种毒性倾向于随所给予的光剂量而变化。绿光剂量大于20J/cm²的全膀胱PDT导致膀胱容量永久性降低。相反，20J/cm²的绿光剂量以及20至60J/cm²的红光剂量并未导致膀胱容量出现任何显著的永久性降低。因此，虽然绿光对膀胱的毒性可能比红光更大，但存在红光或绿光与卟吩姆钠的特定组合，可用于犬膀胱以实现黏膜降解而不引起永久性膀胱功能障碍。
