犬膀胱模型中光动力疗法对膀胱作用的介导因素研究。

Study of factors mediating effect of photodynamic therapy on bladder in canine bladder model.

作者信息

Nseyo U O, Dougherty T J, Boyle D G, Potter W R

机构信息

Department of Radiation Medicine, Roswell Park Memorial Institute, Buffalo, New York.

出版信息

Urology. 1988 Jul;32(1):41-5. doi: 10.1016/0090-4295(88)90451-7.

DOI:10.1016/0090-4295(88)90451-7

PMID:2968705

Abstract

The canine bladder model was employed to study the factors mediating the effect of photodynamic therapy (PDT) on the bladder. The recovery (time taken for the bladder volume to return to pre-PDT value), gross and microscopic findings, implicate both bladder high filling pressure (60 cm H2O) and high light dose as factors mediating the effect of photodynamic therapy on bladder capacity. We recommend that photodynamic therapy to the bladder be performed under a filling pressure of 30 cm H2O, which is physiologic, and whole bladder illumination at a light dose not greater than 30 J/cm2.

摘要

采用犬膀胱模型研究介导光动力疗法（PDT）对膀胱作用的因素。恢复情况（膀胱容积恢复至 PDT 前值所需时间）、大体及显微镜检查结果表明，膀胱高充盈压（60 cm H2O）和高光剂量均为介导光动力疗法对膀胱容量作用的因素。我们建议，对膀胱进行光动力治疗时应在 30 cm H2O 的充盈压（这是生理压力）下进行，并以不大于 30 J/cm2 的光剂量对整个膀胱进行照射。