Amitai Y, Kennedy E, DeSandre P, Fawcett J, Frischer H
Department of Pharmacology (Genetics), Rush-Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.
Vet Hum Toxicol. 1993 Apr;35(2):134-6.
To study the distribution of fluoxetine and norfluoxetine in blood compartments we determined their concentrations in red cells and plasma after the addition of 500 ng/ml of each compound to human blood in vitro. Red cell and plasma fluoxetine concentrations were 493 +/- 79 ng/ml and 454 +/- 53 ng/ml, respectively (P > 0.1). To assess the potential implications of this distribution on routine monitoring of these compounds in plasma, we determined fluoxetine and norfluoxetine concentrations in red cells and plasma in 6 patients receiving various doses of fluoxetine. While in 4 patients the concentrations of fluoxetine and norfluoxetine in red cells and plasma were comparable, 2 patients had higher concentrations of both compounds in red cells. Variations in the distribution of fluoxetine and norfluoxetine in blood compartments are relatively small. Plasma levels may reflect the drug concentration in whole blood more reliably for fluoxetine and norfluoxetine than for tricyclic antidepressants.
为研究氟西汀和去甲氟西汀在血液各组分中的分布情况，我们在体外向人血中添加500 ng/ml的每种化合物后，测定了它们在红细胞和血浆中的浓度。红细胞和血浆中氟西汀的浓度分别为493±79 ng/ml和454±53 ng/ml（P>0.1）。为评估这种分布对这些化合物在血浆中常规监测的潜在影响，我们测定了6例接受不同剂量氟西汀治疗患者的红细胞和血浆中氟西汀和去甲氟西汀的浓度。虽然4例患者红细胞和血浆中氟西汀和去甲氟西汀的浓度相当，但2例患者红细胞中这两种化合物的浓度更高。氟西汀和去甲氟西汀在血液各组分中的分布差异相对较小。对于氟西汀和去甲氟西汀，血浆水平可能比三环类抗抑郁药更可靠地反映全血中的药物浓度。
