Granström M, Granström G
Department of Clinical Microbiology, Karolinska Hospital, Stockholm, Sweden.
Vaccine. 1993;11(4):445-8. doi: 10.1016/0264-410x(93)90286-7.
Antibody concentrations to three Bordetella pertussis antigens in 94 predisease samples from women who, within a median of 220 days, developed culture-confirmed whooping cough were compared to antibodies in samples from matched controls. The median IgG antibody levels were significantly lower to all three antigens, pertussis toxin, filamentous haemagglutinin and lipopolysaccharide, in the predisease samples of cases as compared to non-cases (p values ranging from 0.0001 to 0.01). A significant difference in antibody distribution was, however, found only to pertussis toxin, measured either by ELISA or by a neutralization test (p values of 0.0004 and 0.007, respectively). The results could be interpreted as meaning that antibodies to the different antigens all participate in protection against disease but that antibodies to pertussis toxin play a major role.
对94名在中位数为220天内确诊为培养阳性百日咳的女性发病前样本中三种百日咳博德特氏菌抗原的抗体浓度，与匹配对照样本中的抗体进行了比较。与非病例相比，病例发病前样本中针对所有三种抗原（百日咳毒素、丝状血凝素和脂多糖）的IgG抗体水平中位数显著更低（p值范围为0.0001至0.01）。然而，仅通过ELISA或中和试验检测发现，百日咳毒素的抗体分布存在显著差异（p值分别为0.0004和0.007）。这些结果可以解释为，针对不同抗原的抗体均参与疾病防护，但百日咳毒素抗体起主要作用。
