Kirsch L S, Brownstein S
Department of Ophthalmology, McGill University, Royal Victoria Hospital, Montreal, Canada.
Am J Ophthalmol. 1993 Apr 15;115(4):460-5. doi: 10.1016/s0002-9394(14)74447-2.
In six patients we reviewed the clinical, microbiologic, and histopathologic findings of seven hydrophilic contact lenses that had been infiltrated by fungi. Three patients had visual blurring or irritation and redness while wearing a contaminated lens; of these, two were unaware of any lens deposits. Three of the lenses from two patients were spares kept in storage for six months and one year, respectively. One contaminated lens had been torn and was kept in a case while a loaner lens was worn. Culture of this lens grew Cladosporium species. The contact lens case from one patient grew Penicillium species. Gross pathologic inspection disclosed multiple brown deposits in five lenses, multiple gray infiltrates in one lens, and a white infiltrate in one lens. Light microscopic examination disclosed partial-thickness (three lenses) or full-thickness (four lenses) invasion of the lens matrix by fungi, which contained granular, brown pigment in six lenses.
我们回顾了6例患者中7副被真菌浸润的亲水性隐形眼镜的临床、微生物学和组织病理学检查结果。3例患者在佩戴受污染镜片时出现视力模糊、刺激感和眼红；其中2例未意识到镜片有任何沉积物。来自2例患者的3副镜片是分别保存了6个月和1年的备用镜片。1副受污染的镜片已破损，在佩戴借用镜片时被放在盒中。该镜片培养出枝孢菌属。1例患者的隐形眼镜盒培养出青霉菌属。大体病理学检查发现5副镜片有多处棕色沉积物，1副镜片有多处灰色浸润，1副镜片有白色浸润。光学显微镜检查发现真菌对镜片基质有部分厚度（3副镜片）或全厚度（4副镜片）的侵犯，6副镜片中有真菌含有颗粒状棕色色素。
