Parks D J, Abrams D A, Sarfarazi F A, Katz H R
Krieger Eye Institute, Sinai Hospital of Baltimore, MD 21215.
Am J Ophthalmol. 1993 Apr 15;115(4):471-7. doi: 10.1016/s0002-9394(14)74449-6.
We evaluated the efficacy of ciprofloxacin (3 mg/ml) as the sole topical antibiotic used to treat infectious keratitis in 14 patients. We compared the ciprofloxacin-treated group to a retrospective control group of 30 consecutive culture-positive patients treated with conventional therapy in which cefazolin (50 mg/ml) and fortified gentamicin sulfate (9.1 mg/ml) solutions were used. We found no remarkable difference between the control group and the ciprofloxacin-treated group regarding patient age, risk factors, need for hospitalization, and virulence of organism isolated. The average time to healing in culture-positive ciprofloxacin-treated patients was 34 +/- 33 days vs 45 +/- 71 days in the control group and this difference was not statistically significant. The duration of antibiotic therapy in the culture-positive ciprofloxacin-treated group was 27 +/- 15 days vs 33 +/- 50 days in the control group. Four of the 30 control patients required modification of their antibiotic regimen, whereas no ciprofloxacin-treated patient required a change. Ciprofloxacin appears to be an effective single agent in the treatment of ulcerative keratitis.
我们评估了环丙沙星（3毫克/毫升）作为唯一局部使用的抗生素治疗14例感染性角膜炎患者的疗效。我们将环丙沙星治疗组与一个回顾性对照组进行比较，该对照组由30例连续接受传统治疗的培养阳性患者组成，传统治疗使用头孢唑林（50毫克/毫升）和强化硫酸庆大霉素（9.1毫克/毫升）溶液。我们发现，在患者年龄、危险因素、住院需求以及分离出的病原体毒力方面，对照组和环丙沙星治疗组之间没有显著差异。培养阳性的环丙沙星治疗患者的平均愈合时间为34±33天，而对照组为45±71天，且这种差异无统计学意义。培养阳性的环丙沙星治疗组的抗生素治疗持续时间为27±15天，而对照组为33±50天。30例对照患者中有4例需要调整抗生素治疗方案，而环丙沙星治疗的患者均无需更改治疗方案。环丙沙星似乎是治疗溃疡性角膜炎的一种有效单一药物。
