Melefors O, Hentze M W
European Molecular Biology Laboratory, Heidelberg, Germany.
Bioessays. 1993 Feb;15(2):85-90. doi: 10.1002/bies.950150203.
The expression of certain eukaryotic genes is--at least in part--controlled at the level of mRNA translation. The step of translational initiation represents the primary target for regulation. The regulation of the intracellular iron storage protein ferritin in response to iron levels provides a good example of translational control by a reversible RNA/protein interaction in the 5' untranslated region of an mRNA. We consider mechanisms by which mRNA/protein interactions may impede translation initiation and discuss recent data suggesting that the ferritin example may represent the 'tip of the iceberg' of a more general theme for translational control.
某些真核基因的表达——至少部分地——在mRNA翻译水平受到调控。翻译起始步骤是调控的主要靶点。细胞内铁储存蛋白铁蛋白对铁水平的响应调节，为mRNA 5'非翻译区中可逆的RNA/蛋白质相互作用介导的翻译控制提供了一个很好的例子。我们探讨了mRNA/蛋白质相互作用可能阻碍翻译起始的机制，并讨论了最近的数据，这些数据表明铁蛋白的例子可能代表了翻译控制这一更普遍主题的“冰山一角”。
