Rorarius M G, Suominen P, Baer G A, Romppanen O, Tuimala R
Department of Anaesthesiology, University Hospital, Tampere, Finland.
Br J Anaesth. 1993 Mar;70(3):293-7. doi: 10.1093/bja/70.3.293.
We have studied the effect of a constant infusion of diclofenac 150 mg/24 h, ketoprofen 200 mg/24 h or placebo on postoperative pain after elective Caesarean section performed under spinal or extradural block in 90 patients in a prospective, randomized and double-blind study. During the first 24 h after operation, patients in the treatment groups were more comfortable than the placebo group (P < 0.005); the diclofenac group needed a mean of oxycodone 21.6 mg/24 h and the ketoprofen group 21.2 mg/24 h, compared with 38.3 mg/24 in the placebo group (P < 0.001); the mean time to the first injection of oxycodone was 270.5 min in the diclofenac group, 270.2 min in the ketoprofen group and 161.2 min in the placebo group (P < 0.001). During the first 24 h after operation, the temperature increased in the control group by 0.7 degrees C compared with 0.1 degrees C in the diclofenac group and 0.3 degrees C in the ketoprofen group. One patient in the diclofenac group was eliminated from the study because of uterine relaxation during the first 30 min after start of the drug infusion; this improved after cessation of diclofenac and infusion of sulprostone. There were no other serious side effects.
我们在一项前瞻性、随机双盲研究中，对90例行脊髓或硬膜外阻滞下择期剖宫产术后的患者，研究了持续输注双氯芬酸150mg/24小时、酮洛芬200mg/24小时或安慰剂对术后疼痛的影响。术后最初24小时内，治疗组患者比安慰剂组更舒适（P<0.005）；双氯芬酸组平均每24小时需要羟考酮21.6mg，酮洛芬组为21.2mg，而安慰剂组为38.3mg/24小时（P<0.001）；双氯芬酸组首次注射羟考酮的平均时间为270.5分钟，酮洛芬组为270.2分钟，安慰剂组为161.2分钟（P<0.001）。术后最初24小时内，对照组体温升高0.7摄氏度，双氯芬酸组为0.1摄氏度，酮洛芬组为0.3摄氏度。双氯芬酸组有1例患者在开始输注药物后的最初30分钟内出现子宫松弛，退出研究；停用双氯芬酸并输注硫前列酮后情况改善。无其他严重副作用。
