Rorarius M G, Baer G A, Metsä-Ketelä T
Department of Anaesthesiology, Tampere University Hospital, Finland.
Agents Actions. 1993 Mar;38(3-4):286-9. doi: 10.1007/BF01976222.
Non-steroidal anti-inflammatory drugs obviously act also on the central nervous system. We, therefore, studied the effect of diclofenac 3 mg/kg and ketoprofen 4 mg/kg on the minimum alveolar concentration (MAC) of halothane in 10 New Zealand White rabbits. After determination of halothane MAC, total doses of NSAIDs were administered intravenously as three subdoses: 12.5%, 37.5% and 50% of the total dose. Depth of anaesthesia did not increase significantly after the first two doses with either drug. With ketoprofen, halothane MAC increased after subdose 3 from 1.52 (SD 0.42) vol% to 1.9 (SD 0.36) vol% (p < 0.01). With diclofenac, halothane MAC increased after subdose 3 from 1.44 (SD 0.18) vol% to 1.60 (SD 0.39) vol% (ns). With both drugs, large interindividual differences of MAC appeared after full doses of NSAIDs.
非甾体抗炎药显然也作用于中枢神经系统。因此，我们研究了3毫克/千克双氯芬酸和4毫克/千克酮洛芬对10只新西兰白兔氟烷最低肺泡浓度（MAC）的影响。在测定氟烷MAC后，非甾体抗炎药的总剂量以三次分剂量静脉给药：总剂量的12.5%、37.5%和50%。两种药物在前两剂给药后麻醉深度均未显著增加。使用酮洛芬时，第3次分剂量给药后氟烷MAC从1.52（标准差0.42）体积%增加到1.9（标准差0.36）体积%（p<0.01）。使用双氯芬酸时，第3次分剂量给药后氟烷MAC从1.44（标准差0.18）体积%增加到1.60（标准差0.39）体积%（无统计学意义）。使用两种药物时，在给予全剂量非甾体抗炎药后，MAC出现了较大的个体差异。
