Song C W, Clement J J, Levitt S H
Radiology. 1977 Apr;123(1):201-5. doi: 10.1148/123.1.201.
The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5- thio-D-glucose may be useful adjuvant to radiotherapy
