Derksen J, Moolenaar A J, Van Seters A P, Kock D F
Department of Endocrinology and Metabolism, University Hospital Leiden, The Netherlands.
Br J Dermatol. 1993 Mar;128(3):259-63. doi: 10.1111/j.1365-2133.1993.tb00168.x.
Many doctors frequently encounter hirsute patients. Quantification of hair growth may be useful for diagnosis and follow-up. To establish the reference range for distribution and density of hair in females, and to determine the regions yielding the best discrimination between normal and hirsute women, we studied the distribution and density of terminal hair on 12 body regions assessed on a scale of 0-4. Prospectively, 81 healthy female volunteers and 71 hirsute patients of child-bearing age and Dutch ancestry, who were not receiving medication, and who had not had a recent pregnancy were studied. The reference hair pattern was established for each body region, and the threshold value yielding the highest sensitivity and specificity to evaluate hirsutism was calculated. None of the women in the reference population displayed a score of more than 1 for chin, upper back, upper abdomen and upper arm, or more than 2 for upper lip, side-burns, chest, lower back, lower abdomen, thighs or forearm. The best discrimination between the reference and hirsute populations was obtained with the sum of the scores for four regions: upper lip, chin, lower abdomen and thighs. Independent assessment of hair growth by two investigators revealed excellent agreement. We conclude that a score of more than 1 for chin, upper back, upper abdomen and upper arm, or more than 2 for upper lip, side-burns, chest, lower back, lower abdomen, thighs or forearm is abnormal for Dutch women, and that assessment of hair growth on the upper lip, chin, lower abdomen and thighs is the most suitable way to evaluate hirsutism.
许多医生经常会遇到多毛的患者。毛发生长的量化对于诊断和随访可能有用。为了确定女性毛发分布和密度的参考范围，并确定能最好地区分正常女性和多毛女性的区域，我们研究了12个身体部位终毛的分布和密度，评估范围为0至4级。前瞻性地，我们研究了81名健康的荷兰裔育龄女性志愿者以及71名未接受药物治疗且近期未怀孕的多毛患者。为每个身体部位建立了参考毛发模式，并计算出对评估多毛症具有最高敏感性和特异性的阈值。在参考人群中，没有女性的下巴、上背部、上腹部和上臂得分超过1分，或者上唇、鬓角、胸部、下背部、下腹部、大腿或前臂得分超过2分。通过上唇、下巴、下腹部和大腿这四个区域得分总和，能最好地区分参考人群和多毛人群。两名研究人员对毛发生长进行的独立评估显示出高度一致性。我们得出结论，对于荷兰女性而言，下巴、上背部、上腹部和上臂得分超过1分，或者上唇、鬓角、胸部、下背部、下腹部、大腿或前臂得分超过2分即为异常，而上唇、下巴、下腹部和大腿的毛发生长评估是评估多毛症最合适的方法。
