Bychkova V E, Ptitsyn O B
Biofizika. 1993 Jan-Feb;38(1):58-66.
A review of experimental data concerning physical properties of globular protein at mild denatured conditions shows that at the present time about 20th proteins were obtained in the "molten globule" state at mild denatured conditions (acid or basic pH, high temperature or moderate concentrations of guanidine hydrochloride or urea). This state is nearly as compact as the native state and has a well pronounced secondary structure but has no rigid tertiary structure. A possible role of the molten globule state in the processes of formation and of degradation of globular proteins are discussed.
对有关球状蛋白质在温和变性条件下物理性质的实验数据进行的综述表明，目前约有20种蛋白质在温和变性条件下（酸性或碱性pH值、高温或中等浓度的盐酸胍或尿素）以“熔球态”获得。这种状态几乎与天然状态一样紧密，具有明显的二级结构，但没有刚性的三级结构。文中讨论了熔球态在球状蛋白质形成和降解过程中可能发挥的作用。
