Ledda F, Amerini S, Filippi S, Mantelli L, Morbidelli L, Rubino A, Ziche M
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Cardioscience. 1993 Mar;4(1):1-7.
Calcitonin gene-related peptide, the main transmitter released from capsaicin-sensitive sensory-motor fibers, has positive inotropic and chronotropic effects on the heart and causes vasodilatation in the coronary arteries and elsewhere in the peripheral vasculature. We review some aspects of the cardiovascular actions induced by exogenous calcitonin gene-related peptide and by release of the peptide following activation of capsaicin-sensitive nerves. The efferent function of cardiac sensory-motor neurones is modulated by a number of endogenous substances of physiopathological interest, including opioid peptides, norepinephrine and adenosine. The receptors involved in the prejunctional regulation due to these substances have been characterized. Studies on the mesenteric bed of the rat have shown that, at least in such a resistance vascular bed, the relaxing effect of calcitonin gene-related peptide is mediated by a direct mechanism independent of endothelium-derived nitric oxide release. In cultured human endothelial cells from the umbilical cord vein, calcitonin gene-related peptide, at nM concentrations, stimulates cell growth in a dose-dependent manner. The possible implications of calcitonin gene-related peptide in the physio-pathological regulation of the cardiovascular system and in the trophism of vascular tissues are discussed.
降钙素基因相关肽是由辣椒素敏感的感觉运动纤维释放的主要递质，对心脏具有正性变力和变时作用，并可使冠状动脉及外周血管系统其他部位的血管扩张。我们综述了外源性降钙素基因相关肽以及辣椒素敏感神经激活后肽释放所诱导的心血管作用的一些方面。心脏感觉运动神经元的传出功能受多种具有生理病理意义的内源性物质调节，包括阿片肽、去甲肾上腺素和腺苷。已经对这些物质在突触前调节中涉及的受体进行了表征。对大鼠肠系膜床的研究表明，至少在这样一个阻力血管床中，降钙素基因相关肽的舒张作用是由一种独立于内皮衍生一氧化氮释放的直接机制介导的。在来自人脐静脉的培养内皮细胞中，纳摩尔浓度的降钙素基因相关肽以剂量依赖的方式刺激细胞生长。本文讨论了降钙素基因相关肽在心血管系统生理病理调节和血管组织营养方面的可能意义。
