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病例报告:环孢素A诱导的神经毒性。

Case report: cyclosporin A-induced neurotoxicity.

作者信息

Monteiro L, Almeida-Pinto J, Rocha N, Lopes G, Rocha J

机构信息

Department of Neurology, Hospital Geral de Santo António, Oporto, Portugal.

出版信息

Br J Radiol. 1993 Mar;66(783):271-2. doi: 10.1259/0007-1285-66-783-271.

Abstract

Acute encephalopathy is a recognized toxic effect of Cyclosporin A (CsA) in organ transplantation recipients. A 16-year-old girl presented with acute encephalopathy 2 weeks after CsA and methylprednisolone medication for idiopathic uveitis. Magnetic resonance imaging showed cortical and white matter occipital changes, which were not visible 2 months later. With expanding indication for CsA use, an increasing number of neurotoxic cases are to be expected.

摘要

急性脑病是环孢素A(CsA)在器官移植受者中公认的毒性作用。一名16岁女孩在使用CsA和甲基泼尼松龙治疗特发性葡萄膜炎2周后出现急性脑病。磁共振成像显示枕叶皮质和白质有改变,2个月后这些改变消失。随着CsA使用指征的扩大,预计会出现越来越多的神经毒性病例。

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