Pace M T, Slovis T L, Kelly J K, Abella S D
Department of Radiology, Harper-Grace Hospital, Detroit, MI 48235, USA.
Pediatr Radiol. 1995;25(3):180-3. doi: 10.1007/BF02021528.
Neurotoxicity is a recognized complication with the use of Cyclosporin A (CSA) in bone marrow and organ transplantation patients. Most common symptoms are seizures and altered mental status which are usually transient. We report three cases of transient neurotoxic episodes in patients receiving CSA after a bone marrow transplant. There were reversible low-attenuation changes on CT and bright T2-weighted signal changes on MRI in the cortex and/or white matter of the cerebral hemispheres. All three patients, when given lower maintenance doses of CSA, were free of recurrent neurotoxic effects.
神经毒性是骨髓和器官移植患者使用环孢素A（CSA）时公认的一种并发症。最常见的症状是癫痫发作和精神状态改变，这些症状通常是短暂的。我们报告了3例骨髓移植后接受CSA治疗的患者发生短暂性神经毒性发作的病例。CT显示大脑半球皮质和/或白质有可逆性低密度改变，MRI显示T2加权像上有高信号改变。所有3例患者在给予较低维持剂量的CSA后，均未出现复发性神经毒性反应。
