Rosenfield N S, McIntosh S
Radiology. 1977 May;123(2):413-5. doi: 10.1148/123.2.413.
Serial knee radiographs were obtained from 58 children with leukemia. Leukemic bone changes were found in approximately half of those radiographed at the time of diagnosis but were consistently absent in children older than 10 years. The bone abnormalities persisted for as long as 10 months after treatment was started and did not occur or reappear at the time of relapse. Dense metaphyses simulating the appearance of lead poisoning developed in 20 of 58 patients during chemotherapy.
对58名白血病患儿进行了膝关节系列X光片检查。在诊断时进行X光检查的患儿中，约有一半发现了白血病骨骼改变，但10岁以上的儿童中始终未出现此类改变。骨骼异常在开始治疗后持续长达10个月，在复发时未出现或再次出现。58名患者中有20名在化疗期间出现了类似铅中毒表现的干骺端致密影。
