Schulman H, Hertelendy F, Salau G
Prostaglandins. 1977 Mar;13(3):577-82. doi: 10.1016/0090-6980(77)90034-x.
A chronic model was utilized in the rabbit to determine the effect of ritodrine hydrochloride infusions on pregnancy. Infusions were carried out for 6 hours in the unanesthetized, conscious animal between the 25 to 27 day of pregnancy. Pre and post infusion blood samples were drawn from a catheter lying at the lower inferior vena cava and analyzed for prostaglandin E and F, and progesterone. As compared to a control animal, there was a significant fall in prostaglandin E after 6 hour infusion of drug, but no change in prostaglandin F or progesterone was observed.
在兔子身上建立慢性模型，以确定静脉输注盐酸利托君对妊娠的影响。在妊娠第25至27天，对未麻醉的清醒动物进行6小时的输注。从位于下腔静脉的导管采集输注前后的血样，分析前列腺素E、F和孕酮。与对照动物相比，输注药物6小时后前列腺素E显著下降，但未观察到前列腺素F或孕酮有变化。
