雾化吸入色甘酸钠对早产儿的支气管扩张作用

Bronchodilator effect of nebulized sodium cromoglycate in children born prematurely.

作者信息

Yuksel B, Greenough A

机构信息

Dept of Child Health, King's College Hospital, London, UK.

出版信息

Eur Respir J. 1993 Mar;6(3):387-90.

PMID:8472830

Abstract

We wished to determine whether nebulized sodium cromoglycate (SCG) has bronchodilator effects in very young children. In 18 children born prematurely and studied at a median of 15 months of age, thoracic gas volume (TGV) and airways resistance (Raw), were measured and hence specific airways conductance (sGaw) was calculated before (baseline) and after nebulized saline, and then after sodium cromoglycate. sGaw improved significantly in 10 infants after SCG, compared to only in two following saline. These preliminary results suggest that nebulized SCG may have an acute bronchodilator effect in some children born prematurely.

摘要

我们希望确定雾化吸入色甘酸钠（SCG）对幼儿是否具有支气管扩张作用。对18名早产儿童进行研究，这些儿童的年龄中位数为15个月，测量了他们的胸气体容积（TGV）和气道阻力（Raw），并由此计算出比气道传导率（sGaw），分别在雾化吸入生理盐水前（基线）、吸入生理盐水后以及吸入色甘酸钠后进行测量。与仅在吸入生理盐水后只有两名婴儿的sGaw改善相比，10名婴儿在吸入SCG后sGaw有显著改善。这些初步结果表明，雾化吸入SCG可能对一些早产儿童具有急性支气管扩张作用。