一个新鉴定出的结核分枝杆菌基因的序列，该基因编码一种与毒力调节蛋白具有序列同源性的蛋白质。
Sequence of a newly identified Mycobacterium tuberculosis gene encoding a protein with sequence homology to virulence-regulating proteins.
作者信息
Gupta S, Tyagi A K
机构信息
Department of Biochemistry, University of Delhi South Campus, India.
出版信息
Gene. 1993 Apr 15;126(1):157-8. doi: 10.1016/0378-1119(93)90607-5.
PMID:8472958
Abstract
Analysis of the nucleotide sequence of a gene cloned from a Mycobacterium tuberculosis H37Rv genomic library predicted a 339-amino-acid protein with an M(r) of 37,656. The protein exhibited significant homology with the Cfad, FapR and Rns proteins from different enterotoxigenic strains of Escherichia coli, VirF protein of Shigella and VirFy protein of Yersinia, all of which regulate virulence-associated genes.
摘要
对从结核分枝杆菌H37Rv基因组文库中克隆的一个基因的核苷酸序列分析预测，该基因编码一个含有339个氨基酸的蛋白质，其相对分子质量为37,656。该蛋白质与来自不同产肠毒素大肠杆菌菌株的Cfad、FapR和Rns蛋白、志贺氏菌的VirF蛋白以及耶尔森氏菌的VirFy蛋白具有显著同源性，所有这些蛋白均调控与毒力相关的基因。
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