自然杀伤细胞与肿瘤坏死因子-α介导的小鼠肠道病变

Natural killer cells and tumour necrosis factor-alpha-mediated enteropathy in mice.

作者信息

Garside P, Mowat A M

机构信息

Department of Immunology, Western Infirmary, University of Glasgow.

出版信息

Immunology. 1993 Feb;78(2):335-7.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421823/

Abstract

We have shown previously that normal mice given interferon-alpha/beta (IFN-alpha/beta) or tumour necrosis factor-alpha (TNF-alpha) develop marked intestinal pathology which is similar to that found in enteropathies associated with cell-mediated immunity in vivo, such as graft-versus-host reaction (GVHR). The enteropathy induced by IFN-alpha/beta and GVHR are both dependent on the presence of natural killer (NK) cells and here we have examined whether NK cells are also required for enteropathy caused by TNF-alpha. Mice injected with recombinant TNF-alpha displayed enhanced splenic NK cell activity and developed significant villus atrophy and crypt hypertrophy in the small intestine. Administration of anti-asialo GM1 antibody abolished the NK cell activity in both normal and TNF-alpha-injected mice, but had no effect on the enteropathy caused by TNF-alpha. We conclude that NK cells are not required for TNF-alpha to damage the small intestine.

摘要

我们之前已经表明，给予干扰素-α/β（IFN-α/β）或肿瘤坏死因子-α（TNF-α）的正常小鼠会出现明显的肠道病变，这与体内与细胞介导免疫相关的肠病中发现的病变相似，例如移植物抗宿主反应（GVHR）。IFN-α/β诱导的肠病和GVHR都依赖于自然杀伤（NK）细胞的存在，在此我们研究了TNF-α引起的肠病是否也需要NK细胞。注射重组TNF-α的小鼠脾脏NK细胞活性增强，并在小肠中出现明显的绒毛萎缩和隐窝肥大。给予抗去唾液酸GM1抗体消除了正常小鼠和注射TNF-α小鼠的NK细胞活性，但对TNF-α引起的肠病没有影响。我们得出结论，TNF-α损伤小肠不需要NK细胞。

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本文引用的文献

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Gastroenterology. 1982 Aug;83(2):417-23.

2

Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice.小鼠移植物抗宿主反应期间肠道和外周自然杀伤细胞活性的增强。

Transplantation. 1983 Nov;36(5):513-9. doi: 10.1097/00007890-198311000-00009.

3

Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.自然杀伤（NK）细胞衍生的造血集落抑制活性和NK细胞毒性因子。与肿瘤坏死因子的关系以及与免疫干扰素的协同作用。

J Exp Med. 1985 Nov 1;162(5):1512-30. doi: 10.1084/jem.162.5.1512.

4

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5

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6

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