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1
Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.免疫介导性肠病的实验研究。III. 无胸腺小鼠移植物抗宿主反应期间的严重进行性肠病。
Immunology. 1987 Jun;61(2):185-8.
2
Experimental studies of immunologically mediated enteropathy: IV. Correlation between immune effector mechanisms and type of enteropathy during a GvHR in neonatal mice of different ages.免疫介导性肠病的实验研究：IV. 不同年龄新生小鼠移植物抗宿主反应期间免疫效应机制与肠病类型之间的相关性
Clin Exp Immunol. 1988 Apr;72(1):108-12.
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4
Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.抗γ干扰素抗体可预防小鼠移植物抗宿主反应中免疫介导的肠道损伤。
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Experimental studies of immunologically mediated enteropathy. Development of cell mediated immunity and intestinal pathology during a graft-versus-host reaction in irradiated mice.免疫介导性肠病的实验研究。辐照小鼠移植物抗宿主反应过程中细胞介导免疫及肠道病理的发展。
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Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。
J Immunol. 1983 Sep;131(3):1142-8.
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Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine.上皮内淋巴细胞计数和隐窝增生可衡量小鼠小肠移植物抗宿主反应的黏膜成分。
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引用本文的文献

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2
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本文引用的文献

1
"M" cell distribution in follicle-associated epithelium of mouse Peyer's patch.小鼠派尔集合淋巴结滤泡相关上皮中M细胞的分布
Am J Anat. 1980 Oct;159(2):167-75. doi: 10.1002/aja.1001590205.
2
Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine.上皮内淋巴细胞计数和隐窝增生可衡量小鼠小肠移植物抗宿主反应的黏膜成分。
Gastroenterology. 1982 Aug;83(2):417-23.
3
Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.小肠中的超敏反应。6. 小鼠小肠黏膜移植物抗宿主反应的发病机制。
Transplantation. 1981 Sep;32(3):238-43. doi: 10.1097/00007890-198109000-00011.
4
Anti-idiotypic cytotoxic T cells in rats with graft-versus-host disease.移植物抗宿主病大鼠中的抗独特型细胞毒性T细胞。
Nature. 1984;308(5958):463-4. doi: 10.1038/308463a0.
5
Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice.小鼠移植物抗宿主反应期间肠道和外周自然杀伤细胞活性的增强。
Transplantation. 1983 Nov;36(5):513-9. doi: 10.1097/00007890-198311000-00009.
6
Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。
J Immunol. 1983 Sep;131(3):1142-8.
7
Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。
J Immunol. 1983 Nov;131(5):2101-3.
8
Fate of T-lymphocyte injected into immunodeficient allogeneic nude or semi-allogeneic F1 mice: correlation with manifestations of graft-versus-host reaction.注入免疫缺陷的同种异体裸鼠或半同种异体F1小鼠体内的T淋巴细胞的命运：与移植物抗宿主反应表现的相关性。
Immunol Rev. 1983;73:71-86. doi: 10.1111/j.1600-065x.1983.tb01079.x.
9
Granular intraepithelial lymphocytes of the rat small intestine. I. Isolation, presence in T lymphocyte-deficient rats and bone marrow origin.大鼠小肠的颗粒状上皮内淋巴细胞。I. 分离、在T淋巴细胞缺陷大鼠中的存在及骨髓起源
Int Arch Allergy Appl Immunol. 1983;71(4):317-27. doi: 10.1159/000233414.
10
Analysis of natural killer effector and suppressor activity by intraepithelial lymphocytes from mouse small intestine.对来自小鼠小肠的上皮内淋巴细胞的自然杀伤效应和抑制活性的分析。
Clin Exp Immunol. 1983 Apr;52(1):191-8.

免疫介导性肠病的实验研究。III. 无胸腺小鼠移植物抗宿主反应期间的严重进行性肠病。

Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.

作者信息

Mowat A M, Felstein M V, Baca M E

出版信息

Immunology. 1987 Jun;61(2):185-8.

PMID:3496272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453370/
Abstract

The graft-versus-host reaction (GvHR) in unirradiated (CBA X BALB/c)F1 mice normally produces a proliferative enteropathy consisting of crypt hyperplasia and increased numbers of intraepithelial lymphocytes (IEL), but villus atrophy does not occur. Host T lymphocytes can protect animals from the consequences of a GvHR and, in this study, it is shown that athymic (CBA X BALB/c)F1 mice suffer a more severe systemic GvHR than intact hosts, with the unusual feature of specific anti-host cytotoxic T-lymphocyte (CTL) activity. In addition, nude mice not only had more intense crypt hyperplasia in the small intestine, but also had significant villus atrophy. It is concluded that host T cells normally prevent the progression of GvHR in unirradiated animals, and suggested that villus atrophy reflects a more severe form of the delayed-type hypersensitivity (DTH) reaction, the effects of which are normally limited to crypt hyperplasia.

摘要

未受照射的（CBA×BALB/c）F1小鼠中的移植物抗宿主反应（GvHR）通常会产生一种增殖性肠病，其特征为隐窝增生和上皮内淋巴细胞（IEL）数量增加，但不会出现绒毛萎缩。宿主T淋巴细胞可保护动物免受GvHR的影响，在本研究中发现，无胸腺的（CBA×BALB/c）F1小鼠比正常宿主遭受更严重的全身性GvHR，其具有特异性抗宿主细胞毒性T淋巴细胞（CTL）活性这一不寻常特征。此外，裸鼠不仅小肠隐窝增生更明显，还出现了显著的绒毛萎缩。结论是宿主T细胞通常可防止未受照射动物中GvHR的进展，并表明绒毛萎缩反映了一种更严重形式的迟发型超敏反应（DTH），其影响通常仅限于隐窝增生。