• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫介导性肠病的实验研究。II. 自然杀伤细胞在小鼠移植物抗宿主反应肠道阶段中的作用。

Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.

作者信息

Mowat A M, Felstein M V

出版信息

Immunology. 1987 Jun;61(2):179-83.

PMID:3596637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453377/
Abstract

This study has investigated whether natural killer (NK) cells play a protective or an effector role in unirradiated mice with graft-versus-host reaction (GvHR). Treatment of (CBA X BALB/c)F1 mice with anti-asialo GM1 (ASGM1) antibody produced a profound depletion of resting NK-cell activity and also inhibited the normal enhancement of NK activity found after induction of a GvHR with CBA spleen cells. Compared with normal hosts, mice treated with anti-AsGM1 developed less splenomegaly in GvHR and did not show the crypt hyperplasia normally found in this model of GvHR. Anti-AsGM1 also produced a small but significant reduction of intraepithelial lymphocyte (IEL) numbers in the jejunum of control mice. We conclude that intestinal NK cells are an essential component of the local delayed-type hypersensitivity (DTH) reaction which is responsible for the intestinal phase of GvHR in unirradiated mice.

摘要

本研究调查了自然杀伤（NK）细胞在未受照射的移植物抗宿主反应（GvHR）小鼠中是发挥保护作用还是效应作用。用抗去唾液酸GM1（ASGM1）抗体处理（CBA×BALB/c）F1小鼠，可使静息NK细胞活性显著降低，并且抑制在用CBA脾细胞诱导GvHR后发现的NK活性正常增强。与正常宿主相比，用抗AsGM1处理的小鼠在GvHR中脾脏肿大较轻，且未表现出该GvHR模型中通常出现的隐窝增生。抗AsGM1还使对照小鼠空肠中的上皮内淋巴细胞（IEL）数量出现小幅但显著的减少。我们得出结论，肠道NK细胞是局部迟发型超敏反应（DTH）的重要组成部分，该反应介导未受照射小鼠GvHR的肠道阶段。

相似文献

1
Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.免疫介导性肠病的实验研究。II. 自然杀伤细胞在小鼠移植物抗宿主反应肠道阶段中的作用。
Immunology. 1987 Jun;61(2):179-83.
2
Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.免疫介导性肠病的实验研究。III. 无胸腺小鼠移植物抗宿主反应期间的严重进行性肠病。
Immunology. 1987 Jun;61(2):185-8.
3
Experimental studies of immunologically mediated enteropathy: IV. Correlation between immune effector mechanisms and type of enteropathy during a GvHR in neonatal mice of different ages.免疫介导性肠病的实验研究：IV. 不同年龄新生小鼠移植物抗宿主反应期间免疫效应机制与肠病类型之间的相关性
Clin Exp Immunol. 1988 Apr;72(1):108-12.
4
Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.抗γ干扰素抗体可预防小鼠移植物抗宿主反应中免疫介导的肠道损伤。
Immunology. 1989 Sep;68(1):18-23.
5
Depletion of asialo-GM1+ cells from the F1 recipient mice prior to irradiation and transfusion of parental spleen cells prevents mortality to acute graft-versus-host disease and induction of anti-host specific cytotoxic T cells.在对F1代受体小鼠进行照射和输注亲代脾细胞之前，去除其去唾液酸GM1+细胞可预防急性移植物抗宿主病导致的死亡，并阻止抗宿主特异性细胞毒性T细胞的诱导。
Clin Exp Immunol. 1987 Sep;69(3):652-9.
6
Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model.自然杀伤（NK）细胞与移植物抗宿主病（GVHD）：在小鼠P----F1模型中，NK细胞水平与GVHD之间无相关性。
Immunology. 1985 Jan;54(1):121-6.
7
The effects of polyinosinic:polycytidylic acid (pI:C) on the graft-vs-host (GVH) reaction. II. Increased NK-mediated rejection on C57BL/6 lymphocytes by (C57BL/6 X A)F1 mice.聚肌苷酸:聚胞苷酸（pI:C）对移植物抗宿主（GVH）反应的影响。II. （C57BL/6×A）F1小鼠增强对C57BL/6淋巴细胞的自然杀伤细胞介导的排斥反应
J Immunol. 1986 Dec 1;137(11):3420-7.
8
Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。
J Immunol. 1983 Sep;131(3):1142-8.
9
Reduction of acute graft-versus-host disease-related mortality and cytotoxic T lymphocyte induction after pretreatment of the recipient with anti-asialo GM1 antibody in the murine P-to-F1 model.在小鼠P-to-F1模型中，用抗去唾液酸GM1抗体预处理受体后，降低急性移植物抗宿主病相关死亡率并诱导细胞毒性T淋巴细胞
Transplant Proc. 1987 Feb;19(1 Pt 3):2690-1.
10
Natural killer cells and tumour necrosis factor-alpha-mediated enteropathy in mice.自然杀伤细胞与肿瘤坏死因子-α介导的小鼠肠道病变
Immunology. 1993 Feb;78(2):335-7.

引用本文的文献

1
Immunological studies of NK cell-deficient beige mice. II. Analysis of T-lymphocyte functions in beige mice.NK细胞缺陷的米色小鼠的免疫学研究。II. 米色小鼠T淋巴细胞功能分析。
Immunology. 1989 Jan;66(1):131-7.
2
Immunological studies of NK cell-deficient beige mice. I. Defective ability of beige lymphocytes to mediate local and systemic graft-versus-host reactions.NK细胞缺陷型米色小鼠的免疫学研究。I. 米色淋巴细胞介导局部和全身移植物抗宿主反应的能力缺陷。
Immunology. 1989 Jan;66(1):125-30.
3
Natural killer cells and tumour necrosis factor-alpha-mediated enteropathy in mice.自然杀伤细胞与肿瘤坏死因子-α介导的小鼠肠道病变
Immunology. 1993 Feb;78(2):335-7.
4
Experimental studies of immunologically mediated enteropathy. III. Severe and progressive enteropathy during a graft-versus-host reaction in athymic mice.免疫介导性肠病的实验研究。III. 无胸腺小鼠移植物抗宿主反应期间的严重进行性肠病。
Immunology. 1987 Jun;61(2):185-8.
5
Experimental studies of immunologically mediated enteropathy: IV. Correlation between immune effector mechanisms and type of enteropathy during a GvHR in neonatal mice of different ages.免疫介导性肠病的实验研究：IV. 不同年龄新生小鼠移植物抗宿主反应期间免疫效应机制与肠病类型之间的相关性
Clin Exp Immunol. 1988 Apr;72(1):108-12.
6
Biology of natural killer cells.自然杀伤细胞生物学
Adv Immunol. 1989;47:187-376. doi: 10.1016/s0065-2776(08)60664-1.
7
Human intraepithelial lymphocytes.人上皮内淋巴细胞
Springer Semin Immunopathol. 1990;12(2-3):165-90. doi: 10.1007/BF00197504.
8
The role of interferon alpha/beta in the induction of intestinal pathology in mice.干扰素α/β在小鼠肠道病理诱导中的作用。
Immunology. 1991 Oct;74(2):279-83.

本文引用的文献

1
In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.抗去唾液酸GM1的体内效应。I. 裸鼠自然杀伤细胞活性降低及移植瘤生长增强
J Immunol. 1981 Jul;127(1):34-8.
2
Natural killer activity by spleen, lymph node, and thymus cells during the graft-versus-host reaction.移植物抗宿主反应期间脾脏、淋巴结和胸腺细胞的自然杀伤活性。
Transplantation. 1982 Sep;34(3):144-6. doi: 10.1097/00007890-198209000-00006.
3
Characterization of mouse helper and suppressor T cell subsets separated by lectins.用凝集素分离的小鼠辅助性和抑制性T细胞亚群的特性分析
J Immunol. 1980 Nov;125(5):1928-32.
4
Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine.上皮内淋巴细胞计数和隐窝增生可衡量小鼠小肠移植物抗宿主反应的黏膜成分。
Gastroenterology. 1982 Aug;83(2):417-23.
5
Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.小肠中的超敏反应。6. 小鼠小肠黏膜移植物抗宿主反应的发病机制。
Transplantation. 1981 Sep;32(3):238-43. doi: 10.1097/00007890-198109000-00011.
6
A glycolipid on the surface of mouse natural killer cells.小鼠自然杀伤细胞表面的一种糖脂。
Eur J Immunol. 1980 Mar;10(3):175-80. doi: 10.1002/eji.1830100304.
7
Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice.小鼠移植物抗宿主反应期间肠道和外周自然杀伤细胞活性的增强。
Transplantation. 1983 Nov;36(5):513-9. doi: 10.1097/00007890-198311000-00009.
8
Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。
J Immunol. 1983 Sep;131(3):1142-8.
9
Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。
J Immunol. 1983 Nov;131(5):2101-3.
10
Are "natural killer" cells involved in allograft rejection?“自然杀伤”细胞参与同种异体移植排斥反应吗？
Eur J Immunol. 1983 Apr;13(4):348-50. doi: 10.1002/eji.1830130415.