免疫介导性肠病的实验研究。II. 自然杀伤细胞在小鼠移植物抗宿主反应肠道阶段中的作用。

Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.

作者信息

Mowat A M, Felstein M V

出版信息

Immunology. 1987 Jun;61(2):179-83.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453377/

Abstract

This study has investigated whether natural killer (NK) cells play a protective or an effector role in unirradiated mice with graft-versus-host reaction (GvHR). Treatment of (CBA X BALB/c)F1 mice with anti-asialo GM1 (ASGM1) antibody produced a profound depletion of resting NK-cell activity and also inhibited the normal enhancement of NK activity found after induction of a GvHR with CBA spleen cells. Compared with normal hosts, mice treated with anti-AsGM1 developed less splenomegaly in GvHR and did not show the crypt hyperplasia normally found in this model of GvHR. Anti-AsGM1 also produced a small but significant reduction of intraepithelial lymphocyte (IEL) numbers in the jejunum of control mice. We conclude that intestinal NK cells are an essential component of the local delayed-type hypersensitivity (DTH) reaction which is responsible for the intestinal phase of GvHR in unirradiated mice.

摘要

本研究调查了自然杀伤（NK）细胞在未受照射的移植物抗宿主反应（GvHR）小鼠中是发挥保护作用还是效应作用。用抗去唾液酸GM1（ASGM1）抗体处理（CBA×BALB/c）F1小鼠，可使静息NK细胞活性显著降低，并且抑制在用CBA脾细胞诱导GvHR后发现的NK活性正常增强。与正常宿主相比，用抗AsGM1处理的小鼠在GvHR中脾脏肿大较轻，且未表现出该GvHR模型中通常出现的隐窝增生。抗AsGM1还使对照小鼠空肠中的上皮内淋巴细胞（IEL）数量出现小幅但显著的减少。我们得出结论，肠道NK细胞是局部迟发型超敏反应（DTH）的重要组成部分，该反应介导未受照射小鼠GvHR的肠道阶段。

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本文引用的文献

1

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.抗去唾液酸GM1的体内效应。I. 裸鼠自然杀伤细胞活性降低及移植瘤生长增强

J Immunol. 1981 Jul;127(1):34-8.

2

Natural killer activity by spleen, lymph node, and thymus cells during the graft-versus-host reaction.移植物抗宿主反应期间脾脏、淋巴结和胸腺细胞的自然杀伤活性。

Transplantation. 1982 Sep;34(3):144-6. doi: 10.1097/00007890-198209000-00006.

3

Characterization of mouse helper and suppressor T cell subsets separated by lectins.用凝集素分离的小鼠辅助性和抑制性T细胞亚群的特性分析

J Immunol. 1980 Nov;125(5):1928-32.

4

Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine.上皮内淋巴细胞计数和隐窝增生可衡量小鼠小肠移植物抗宿主反应的黏膜成分。

Gastroenterology. 1982 Aug;83(2):417-23.

5

Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.小肠中的超敏反应。6. 小鼠小肠黏膜移植物抗宿主反应的发病机制。

Transplantation. 1981 Sep;32(3):238-43. doi: 10.1097/00007890-198109000-00011.

6

A glycolipid on the surface of mouse natural killer cells.小鼠自然杀伤细胞表面的一种糖脂。

Eur J Immunol. 1980 Mar;10(3):175-80. doi: 10.1002/eji.1830100304.

7

Augmentation of intestinal and peripheral natural killer cell activity during the graft-versus-host reaction in mice.小鼠移植物抗宿主反应期间肠道和外周自然杀伤细胞活性的增强。

Transplantation. 1983 Nov;36(5):513-9. doi: 10.1097/00007890-198311000-00009.

8

Modulation of F1 cytotoxic potentials by GvHR. Host- and donor-derived cytotoxic lymphocytes arise in the unirradiated F1 host spleens under the condition of GvHR-associated immunosuppression.移植物抗宿主反应对F1细胞毒性潜能的调节。在移植物抗宿主反应相关免疫抑制条件下，宿主和供体来源的细胞毒性淋巴细胞在未受照射的F1宿主脾脏中产生。

J Immunol. 1983 Sep;131(3):1142-8.

9

Prevention of lethal, minor-determinate graft-host disease in mice by the in vivo administration of anti-asialo GM1.通过体内给予抗唾液酸GM1预防小鼠致死性、微小决定性移植物抗宿主病。

J Immunol. 1983 Nov;131(5):2101-3.

10

Are "natural killer" cells involved in allograft rejection?“自然杀伤”细胞参与同种异体移植排斥反应吗？

Eur J Immunol. 1983 Apr;13(4):348-50. doi: 10.1002/eji.1830130415.

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