Scheid P, Kuhlmann W D, Fedde M R
Respir Physiol. 1977 Feb;29(1):49-62. doi: 10.1016/0034-5687(77)90116-5.
Intrapulmonary receptors identified in the Tegu lizard by single-unit vagal recording (Fedde et al., 1977) were subjected to a number of stimuli and localized within the lung. Some carbon dioxide receptors could follow periodic changes in intrapulmonary CO2 concentrations as rapidly as 1.3 Hz; No oxygen sensitivity was observed with this receptor type, and halothane markedly depressed the discharge frequency. In response to intravenously injected acetazolamide they increased their discharge frequency and became almost totally insensitive to CO2, suggesting molecular per se is not the direct controller of receptor discharge; These receptors show many of the functional characteristics described for those in the avian lung. Afferent activity from both CO2 and mechanoreceptors could be elicited by electrically stimulating the lung surface. The CO2 receptors appeared to be organized in a receptive field covering more than 1 cm2 of lung surface, multiple receptors being innervated by a single afferent fiber. Activity in afferent fibers from mechanoreceptors could be evoked from only one distinct spot on the lung surface. Conduction velocities of afferent fibers from CO2 receptors ranged from 1 to 3 m-sec-1; from mechanoreceptors, from 1.9 to 5.2 m-sec-1.
通过单单位迷走神经记录在鬃狮蜥中识别出的肺内感受器（Fedde等人，1977年）接受了多种刺激，并定位在肺内。一些二氧化碳感受器能够以高达1.3赫兹的速度跟随肺内二氧化碳浓度的周期性变化；未观察到这种感受器类型对氧气敏感，并且氟烷显著降低了放电频率。静脉注射乙酰唑胺后，它们的放电频率增加，并且几乎对二氧化碳完全不敏感，这表明分子本身不是感受器放电的直接控制因素；这些感受器表现出许多与鸟类肺中感受器所描述的功能特征。通过电刺激肺表面可以引发来自二氧化碳感受器和机械感受器的传入活动。二氧化碳感受器似乎组织成一个覆盖超过1平方厘米肺表面的感受野，多个感受器由单个传入纤维支配。来自机械感受器的传入纤维的活动只能从肺表面的一个独特部位诱发。来自二氧化碳感受器的传入纤维的传导速度范围为1至3米每秒；来自机械感受器的传导速度范围为1.9至5.2米每秒。
