鸟类对二氧化碳的通气反应。II. 肺内二氧化碳受体的作用

Ventilation response to CO2 in birds. II. Contribution by intrapulmonary CO2 receptors.

作者信息

Scheid P, Gratz R K, Powell F L, Fedde M R

出版信息

Respir Physiol. 1978 Dec;35(3):361-72. doi: 10.1016/0034-5687(78)90009-9.

Abstract

The CO2 sensitivity of intrapulmonary CO2 receptors (IPC) in the duck was studied, before (Control) and after blockade of carbonic anhydrase by Diamox, by recording single unit afferent activity in the vagus nerve. During Control, IPC activity decreased with increasing airway CO2 concentration. After Diamox administration, the discharge from IPC was higher at all levels of airway PCO2, and the receptors' CO2 sensitivity was markedly attenuated. Comparing these results with measurements on ventilation and blood gases of the duck under similar experimental conditions (Powell et al., 1978b) suggests that IPC play a role in the adjustment of ventilation to altered concentrations of inspired CO2; IPC may thus be a significant component in the control of breathing under physiological conditions.

摘要

通过记录迷走神经中的单单位传入活动，研究了在（对照）阶段以及用乙酰唑胺阻断碳酸酐酶之后，鸭肺内二氧化碳受体（IPC）对二氧化碳的敏感性。在对照阶段，IPC活动随气道二氧化碳浓度升高而降低。给予乙酰唑胺后，在所有气道PCO₂水平下，IPC的放电频率均更高，并且受体对二氧化碳的敏感性明显减弱。将这些结果与在类似实验条件下对鸭的通气和血气测量结果（鲍威尔等人，1978b）进行比较表明，IPC在调节通气以适应吸入二氧化碳浓度变化中发挥作用；因此，IPC可能是生理条件下呼吸控制的重要组成部分。