Peters S A, Rolles C J
Department of Child Health, Southampton General Hospital, U.K.
J Clin Pharm Ther. 1993 Feb;18(1):33-8. doi: 10.1111/j.1365-2710.1993.tb00563.x.
Vitamin supplements are routinely prescribed in cystic fibrosis, but published recommendations vary widely and there is little consistency in clinical practice. A review of the literature confirms that, while supplementation of the water-soluble vitamins (including B12 and folate) is unnecessary in uncomplicated cystic fibrosis, deficiency of the fat-soluble vitamins can lead to clinical problems. Supplements of these vitamins should be ensured for all patients with cystic fibrosis, while sparing them the unnecessary inconvenience of taking other vitamin supplements except where these are specifically indicated.
囊性纤维化患者通常会常规服用维生素补充剂，但已发表的建议差异很大，临床实践中也缺乏一致性。文献综述证实，虽然在无并发症的囊性纤维化患者中补充水溶性维生素（包括维生素B12和叶酸）并无必要，但脂溶性维生素缺乏会导致临床问题。应确保所有囊性纤维化患者补充这些维生素，同时避免他们因服用其他维生素补充剂而带来不必要的不便，除非有明确指征。
