Saelens D A, Zawada E T, Peterson J, Lembke J M
Department of Internal Medicine, University of South Dakota School of Medicine, Sioux Falls 57105.
J Clin Pharmacol. 1993 Apr;33(4):335-41. doi: 10.1002/j.1552-4604.1993.tb04666.x.
A number of studies have shown an antihypertensive effect for high-calcium diets, but others have found no effect or, even a prohypertensive effect. Because of these disparate results, studies were conducted in spontaneously hypertensive rats (SHR) fed either a normal calcium diet (1.0% calcium) or a high-calcium diet (4.0% calcium) with or without verapamil HCl (50 mg/kg body weight) from ages 5 to 12 weeks. Systolic blood pressure (SBP) and heart rate (HR) were measured by indirect tail cuff method. During the analysis of the electrolytes and vasoactive hormones monitored in this study, it was found that rats fed high-calcium diet had significantly elevated serum ionized and total calcium and calcium excretion. Systolic blood pressure for the verapamil-normal calcium diet (week 5, 148 +/- 4 mm Hg; week 7, 162 +/- 4 mm Hg) did not differ significantly from that of normal calcium diet (week 5, 152 +/- 2 mm Hg; week 7, 160 +/- 1 mm Hg). The high-calcium diet potentiated the development of hypertension, i.e., SBP was (157 +/- 2 mm Hg) on the 5th week and (174 +/- 4 mm Hg) on the 7th week. Conversely, verapamil high-calcium diet prevented the development of hypertension (week 5, SBP was 139 +/- 4 mm Hg; week 7, SBP was 146 +/- 3 mm Hg).(ABSTRACT TRUNCATED AT 250 WORDS)
多项研究表明高钙饮食具有降压作用，但其他研究却未发现其有效果，甚至发现其有升压作用。由于这些不同的结果，对5至12周龄的自发性高血压大鼠（SHR）进行了研究，这些大鼠分别喂食正常钙饮食（1.0%钙）或高钙饮食（4.0%钙），并添加或不添加盐酸维拉帕米（50毫克/千克体重）。通过间接尾套法测量收缩压（SBP）和心率（HR）。在分析本研究中监测的电解质和血管活性激素时，发现喂食高钙饮食的大鼠血清离子钙、总钙和钙排泄量显著升高。维拉帕米 - 正常钙饮食组的收缩压（第5周，148±4毫米汞柱；第7周，162±4毫米汞柱）与正常钙饮食组（第5周，152±2毫米汞柱；第7周，160±1毫米汞柱）无显著差异。高钙饮食会加剧高血压的发展，即第5周时收缩压为（157±2毫米汞柱），第7周时为（174±4毫米汞柱）。相反，维拉帕米 - 高钙饮食可预防高血压的发展（第5周，收缩压为139±4毫米汞柱；第7周，收缩压为146±3毫米汞柱）。（摘要截短于250字）
