Schleiffer R, Pernot F, Berthelot A, Gairard A
Clin Exp Hypertens A. 1984;6(4):783-93. doi: 10.3109/10641968409044038.
Young (5 week old) spontaneously hypertensive rats (SHR) were fed diets modified with respect to their calcium content. Control rats were given a normal calcium diet (0.3 per cent). During the experiment the systolic blood pressure (SBP), heart rate and serum level of total and ionized calcium were measured. Three diets were studied :calcium-free diet (0 per cent, h1), low calcium diet (0.03 per cent, h2) and high calcium diet (1.2 per cent, H). The h1 diet induced a transitory increase (at week 2), then a long-lasting decrease in SBP for 12 weeks. Heart rate and calcemia were significantly decreased. The h2 diet enhanced the increase in SBP and lowered heart rate for 10 weeks. Level of total and ionized serum calcium were unchanged. The high calcium diet (1.2 per cent) attenuated the increase in SBP for 44 weeks and enhanced the heart rate for 16 weeks. The serum level of total calcium remained stable but that of ionized calcium increased significantly at week 7. These data clearly establish that, in young SHR, a low calcium diet enhances the development of genetic hypertension and confirm earlier works obtained with calcium enriched diets. Experimental and clinical data lead us to emphasize the importance of alimentary calcium in the hypertensive pathology.
对5周龄的自发性高血压幼鼠（SHR）喂食钙含量不同的饮食。对照大鼠给予正常钙饮食（0.3%）。在实验期间，测量收缩压（SBP）、心率以及总钙和离子钙的血清水平。研究了三种饮食：无钙饮食（0%，h1）、低钙饮食（0.03%，h2）和高钙饮食（1.2%，H）。h1饮食在第2周引起短暂升高，然后使SBP持续下降12周。心率和血钙显著降低。h2饮食使SBP升高并使心率降低10周。血清总钙和离子钙水平未变。高钙饮食（1.2%）使SBP升高减弱44周，并使心率加快16周。血清总钙水平保持稳定，但离子钙水平在第7周显著升高。这些数据清楚地表明，在幼龄SHR中，低钙饮食会促进遗传性高血压的发展，并证实了早期关于高钙饮食的研究结果。实验和临床数据使我们强调膳食钙在高血压病理中的重要性。
