Fairweather D B, Kerr J S, Hindmarch I
Human Psychopharmacology Research Unit, University of Surrey, Milford Hospital, Godalming, Surrey, UK.
Int Clin Psychopharmacol. 1993 Spring;8(1):43-7. doi: 10.1097/00004850-199300810-00007.
Sixteen young male volunteers received single doses of moclobemide 200 mg, moclobemide 400 mg, amitriptyline 50 mg and placebo in a double-blind crossover study. Subjects then completed a test battery which is sensitive to the effects of psychoactive drugs at 1, 2, and 4 h post-dose. The test battery included tasks of choice reaction time, tracking, critical flicker fusion threshold and memory scanning. Subjective feelings were assessed using the Leeds sleep evaluation questionnaire (LSEQ) and line analogue rating scales (LARS). The results show that the positive internal control (amitriptyline) has a sedative effect in that it increased critical flicker fusion threshold, reaction time and tracking error. Moclobemide 400 mg increased reaction time in the tracking task but neither dose of moclobemide impaired psychomotor performance or cognitive ability in any of the other tests.
在一项双盲交叉研究中，16名年轻男性志愿者接受了单剂量的200毫克吗氯贝胺、400毫克吗氯贝胺、50毫克阿米替林和安慰剂。受试者随后完成了一组对精神活性药物作用敏感的测试，分别在给药后1小时、2小时和4小时进行。测试组包括选择反应时间、跟踪、临界闪烁融合阈值和记忆扫描等任务。使用利兹睡眠评估问卷（LSEQ）和线性模拟评分量表（LARS）评估主观感受。结果表明，阳性内部对照（阿米替林）具有镇静作用，因为它提高了临界闪烁融合阈值、反应时间和跟踪误差。400毫克吗氯贝胺增加了跟踪任务中的反应时间，但两种剂量的吗氯贝胺在任何其他测试中均未损害精神运动表现或认知能力。
