Siepmann M, Handel J, Mueck-Weymann M, Kirch W
Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany.
Pharmacopsychiatry. 2004 Mar;37(2):81-7. doi: 10.1055/s-2004-815530.
Moclobemide, a reversible and selective inhibitor of the MAO-A isoenzyme, is marketed as an antidepressant that lacks autonomic and cognitive side effects. However, only few and inconclusive quantitative data on the effects of moclobemide on autonomic and cognitive functions have been reported in the literature. Therefore, a double-blind, randomized, placebo-controlled crossover trial was performed.
Twelve healthy male volunteers (age 22-29 years) received orally 150 mg moclobemide b.i.d. and placebo for 14 days each. Heart rate variability (HRV) and skin conductance response (SCR) following sudden deep breath were employed as parameters for autonomic function. Quantitative EEG (qEEG) and psychometric tests served as parameters for cognitive function. Measurements were performed before the start of drug administration and repeatedly on the last treatment day.
Parameters of HRV and SCR were not changed by multiple dosing with moclobemide (P > 0.05). Neither cognitive functions such as flicker fusion frequency, memory, choice reaction time, and psychomotor performance nor qEEG was significantly influenced, but subjective tiredness was decreased at all time points of measurement after multiple dosing with moclobemide (P < 0.05).
In conclusion, moclobemide does not appear to influence autonomic functions or cognitive functions when given subchronically to healthy humans. In contrast, changes in subjective mood hint at a subtle activating effect.
吗氯贝胺是一种可逆性和选择性单胺氧化酶-A同工酶抑制剂，作为一种无自主神经和认知副作用的抗抑郁药上市。然而，文献中仅报道了少量关于吗氯贝胺对自主神经和认知功能影响的定量数据，且尚无定论。因此，进行了一项双盲、随机、安慰剂对照的交叉试验。
12名健康男性志愿者（年龄22 - 29岁），分别口服150毫克吗氯贝胺，每日两次，以及安慰剂，各服用14天。以深呼吸后心率变异性（HRV）和皮肤电导反应（SCR）作为自主神经功能参数。定量脑电图（qEEG）和心理测试作为认知功能参数。在给药开始前及最后一个治疗日重复进行测量。
多次服用吗氯贝胺后，HRV和SCR参数未发生变化（P > 0.05）。闪烁融合频率、记忆、选择反应时间和精神运动性能等认知功能以及qEEG均未受到显著影响，但多次服用吗氯贝胺后，在所有测量时间点主观疲劳感均有所降低（P < 0.05）。
总之，对健康人进行亚慢性给药时，吗氯贝胺似乎不会影响自主神经功能或认知功能。相反，主观情绪的变化提示存在细微的激活作用。
