Hollander A P, Dieppe P A, Atkins R M, Elson C J
Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, PQ, Canada.
J Rheumatol. 1993 Feb;20(2):223-4.
Cartilage degradation in rheumatoid arthritis (RA) and osteoarthritis (OA) is commonly thought to be mediated by interleukin 1 (IL-1) and tumor necrosis factor (TNF). However, recent new evidence suggests that IL-1 and TNF on their own do not mediate all the cartilage changes seen in RA and OA. We propose that cartilage degradation is mediated by a complex network of cytokines, including IL-1, TNF and at least one cofactor present in synovial fluid.
类风湿性关节炎（RA）和骨关节炎（OA）中的软骨降解通常被认为是由白细胞介素1（IL-1）和肿瘤坏死因子（TNF）介导的。然而，最近的新证据表明，IL-1和TNF自身并不能介导RA和OA中出现的所有软骨变化。我们提出，软骨降解是由一个复杂的细胞因子网络介导的，包括IL-1、TNF以及滑液中存在的至少一种辅助因子。
