Niinami H, Hooper T L, Hammond R L, Ruggiero R, Lu H, Pochettino A, Stephenson L W
Department of Surgery, Wayne State University, School of Medicine, Detroit, Michigan 48201.
J Surg Res. 1993 Mar;54(3):230-6. doi: 10.1006/jsre.1993.1036.
Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 10 dogs. In Group I (n = 5), SMVs were left in an extrathoracic position on the chest wall. In Group II (n = 5), SMVs were placed within the chest cavity. After a 3- to 4-week vascular delay period, SMVs were electrically preconditioned with 2 Hz continuous stimulation for 6 weeks. At a second procedure, SMVs were connected to a mock circulation system, and function was evaluated under differing conditions of preload and afterload. SMVs in Group II were significantly more compliant, as demonstrated by the end diastolic pressure volume relationship, than those in Group I (P < 0.01). SMVs in Group II were also capable of generating greater stroke work than those in Group I (P < 0.05). SMVs in Group II were also capable of greater stroke work than those in Group I at physiologic preloads (P < 0.05). These findings suggest that SMVs placed in an intrathoracic position exhibit better diastolic and systolic function.
在10只狗身上，利用背阔肌构建了骨骼肌心室（SMV）。在第一组（n = 5）中，将SMV留在胸壁的胸外位置。在第二组（n = 5）中，将SMV置于胸腔内。经过3至4周的血管延迟期后，对SMV进行2赫兹连续刺激的电预处理，持续6周。在第二次手术中，将SMV连接到模拟循环系统，并在不同的前负荷和后负荷条件下评估其功能。通过舒张末期压力容积关系表明，第二组的SMV比第一组的SMV顺应性显著更高（P < 0.01）。第二组的SMV产生的每搏功也比第一组的更大（P < 0.05）。在生理前负荷下，第二组的SMV每搏功也比第一组的更大（P < 0.05）。这些发现表明，置于胸腔内的SMV表现出更好的舒张和收缩功能。
