Van der Weyden M B, Hart J A, Flux M, Dargaville R M, Magrin G
Department of Haematology, Alfred Hospital, Prahran, VIC.
Med J Aust. 1993 Mar 1;158(5):302-4.
To evaluate the safety and efficacy of a preoperative autologous blood donation (PABD) program with liberal patient exclusion criteria.
Prospective patient accrual from September 1990 to May 1992.
A PABD program in a public tertiary care hospital linked with a specialist orthopaedic practice in a private hospital.
One hundred and twenty patients consecutively scheduled for orthopaedic surgery were referred for PABD. There were 77 women (median age, 63 years) and 43 men (median age, 62 years). One-third of patients were 70 or more years old. Coexistent medical disease, mainly cardiovascular, was present in 46% of patients and 3% were excluded because of coexisting morbidity. Total hip or total knee replacement was performed in a private hospital with intraoperative or postoperative blood salvage in 37% of the patients.
Adverse effects of PABD, autologous blood collected and used and homologous blood transfused.
One hundred and sixteen patients donated 267 units of autologous blood. In 70 patients undergoing total hip replacement, 78% donated three and 20% donated two units, with 95% of autologous blood being used. In 38 patients undergoing total knee replacement, 42% donated two units and 55% donated one unit, with 87% of autologous blood being transfused. Seventy-eight per cent of all patients only received autologous blood. In the remaining patients, homologous blood use was confined to two units or less in 80%. Hypotensive episodes associated with phlebotomy occurred in 3% of patients, and 13% of patients had preoperative haemoglobin levels ranging from 85-100 g/L without adverse clinical effects.
A hospital-based PABD program with less strict patient exclusion criteria does not prejudice the clinical status of the donors. Its linkage to private hospitals can significantly reduce the use of homologous blood in selected elective surgery.
评估采用宽松患者排除标准的术前自体血捐献(PABD)计划的安全性和有效性。
1990年9月至1992年5月进行前瞻性患者招募。
一家公立三级护理医院的PABD计划,该医院与一家私立医院的专科骨科诊所相关联。
连续安排进行骨科手术的120名患者被转诊至PABD计划。其中有77名女性(中位年龄63岁)和43名男性(中位年龄62岁)。三分之一的患者年龄在70岁及以上。46%的患者存在并存的内科疾病,主要是心血管疾病,3%的患者因并存疾病而被排除。全髋关节或全膝关节置换手术在一家私立医院进行,37%的患者术中或术后采用血液回收。
PABD的不良反应、采集和使用的自体血以及输注的异体血。
116名患者捐献了267单位自体血。在70名接受全髋关节置换的患者中,78%捐献了3单位,20%捐献了2单位,95%的自体血被使用。在38名接受全膝关节置换的患者中,42%捐献了2单位,55%捐献了1单位,87%的自体血被输注。78%的所有患者仅接受了自体血。在其余患者中,80%的患者异体血使用量限制在2单位或更少。3%的患者发生了与静脉穿刺相关的低血压发作,13%的患者术前血红蛋白水平在85 - 100 g/L之间,无不良临床影响。
基于医院的PABD计划,采用不太严格的患者排除标准不会损害捐献者的临床状况。该计划与私立医院的关联可显著减少特定择期手术中异体血的使用。