MMWR Morb Mortal Wkly Rep. 1993 Apr 30;42(16):312-4.
Although fetal alcohol syndrome (FAS) is a major preventable cause of mental retardation in the United States (1), surveillance for this problem is subject to at least five constraints: difficulty in identifying the syndrome at birth (2); the subjective nature of the diagnosis; variability in the severity and type of conditions associated with FAS; age-specific variations in the expression of the phenotype; and the lack of specificity in the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) code for FAS. Previous studies have documented high rates of FAS among American Indians and Alaskan Natives (ANs) (3,4). To better ascertain cases of FAS in Alaska and to determine the prevalence of this problem among ANs, the Alaska Department of Health and Social Services (ADHSS), the Indian Health Service (IHS), and CDC linked and analyzed data from state sources (i.e., birth and death certificates and Medicaid claims), an IHS case file, and a private pediatric practice case file. This report summarizes the findings from this analysis and presents a preliminary minimum FAS prevalence rate for ANs.
尽管胎儿酒精综合征（FAS）是美国智力发育迟缓的一个主要可预防病因（1），但对该问题的监测至少受到五个限制：出生时难以识别该综合征（2）；诊断具有主观性；与FAS相关的病症严重程度和类型存在差异；表型表达存在年龄特异性差异；以及《国际疾病分类第九版临床修订本》（ICD-9-CM）中FAS编码缺乏特异性。先前的研究记录了美国印第安人和阿拉斯加原住民（ANs）中FAS的高发病率（3,4）。为了更好地确定阿拉斯加FAS病例，并确定该问题在ANs中的患病率，阿拉斯加卫生与社会服务部（ADHSS）、印第安卫生服务局（IHS）和疾病预防控制中心（CDC）对来自州来源（即出生和死亡证明以及医疗补助申请）的数据、一份IHS病例档案和一份私人儿科诊所病例档案进行了关联和分析。本报告总结了该分析的结果，并给出了ANs的初步最低FAS患病率。
