Linazasoro G, Martí Massó J F, Suárez J A
Section of Neurology, Hospital Nuestra Senora de Arantzazu, San Sebastián, Spain.
Mov Disord. 1993 Apr;8(2):171-4. doi: 10.1002/mds.870080209.
We present the results obtained using low doses of clozapine (mean dose 26.4 mg at bedtime) in the treatment of nocturnal akathisia in nine patients with Parkinson's disease for a mean period of 12.5 months. The results were excellent in all the patients. Furthermore, three patients experienced a remarkable improvement in rest tremor and in five patients the confusional state that accompanied the akathisia also disappeared. No serious side-effects were observed. We believe that clozapine is a very useful drug for the relief of nocturnal akathisia in parkinsonian subjects.
