帕金森病和多系统萎缩中睡眠障碍的管理
Management of sleep disorders in Parkinson's disease and multiple system atrophy.
作者信息
Videnovic Aleksandar
机构信息
Movement Disorders Unit and Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Mov Disord. 2017 May;32(5):659-668. doi: 10.1002/mds.26918. Epub 2017 Jan 24.
Abstract
Parkinson's disease (PD) and multiple system atrophy (MSA) are disorders associated with α synuclein-related neurodegeneration. Nonmotor symptoms are common hallmarks of these disorders, and disturbances of the sleep-wake cycle are among the most common nonmotor symptoms. It is only recently that sleep disturbances have received the attention of the medical and research community. Significant progress has been made in understanding the pathophysiology of sleep and wake disruption in alphasynucleinopathies during the past few decades. Despite these advancements, treatment options are limited and frequently associated with problematic side effects. Further studies that center on the development of novel treatment approaches are very much needed. In this article, the author discusses the current state of the management of disturbed sleep and alertness in PD and MSA. © 2017 International Parkinson and Movement Disorder Society.
摘要
帕金森病（PD）和多系统萎缩（MSA）是与α-突触核蛋白相关神经变性有关的疾病。非运动症状是这些疾病的常见特征，而睡眠-觉醒周期紊乱是最常见的非运动症状之一。直到最近，睡眠障碍才受到医学和研究界的关注。在过去几十年里，在理解α-突触核蛋白病中睡眠和觉醒中断的病理生理学方面取得了重大进展。尽管有这些进展，但治疗选择有限，且常常伴有问题副作用。非常需要以开发新治疗方法为中心的进一步研究。在本文中，作者讨论了帕金森病和多系统萎缩中睡眠障碍和警觉性管理的现状。©2017国际帕金森和运动障碍协会。
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Curr Psychiatry Rep. 2016 Oct;18(10):89. doi: 10.1007/s11920-016-0727-9.
2
Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions.特发性快速眼动睡眠行为障碍：诊断、管理和神经保护干预的必要性。
Lancet Neurol. 2016 Apr;15(4):405-19. doi: 10.1016/S1474-4422(16)00057-0.
3
Use of a new generation of adaptive servo ventilation for sleep-disordered breathing in patients with multiple system atrophy.新一代适应性伺服通气在多系统萎缩患者睡眠呼吸障碍中的应用。
BMJ Case Rep. 2015 Nov 6;2015:bcr2014206372. doi: 10.1136/bcr-2014-206372.
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Sleep Med. 2015 Jan;16(1):186-9. doi: 10.1016/j.sleep.2014.08.014. Epub 2014 Nov 13.
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